B6308
Sigma
Biochemistry of Cell Signalling
| ISBN-10: | 0-19-850820-4 |
| ISBN-13: | 978-0-19-850820-5 |
Description
| General description | This will serve as a reliable map through the maze of cell signaling pathways and help the reader understand how malfunctions in these pathways can lead to disease. Part 1 describes the machinery of signal transduction starting with the properties of signals, receptors (including receptor activation), regulators, and the molecules that link receptor and regulator. Part 2 describes the implementation of the signaling cascades focusing on the effect on gene transcription. Part 3 studies the global cellular regulatory programs for the control of cell growth and proliferation. Part 4 considers loss of regulatory control and its consequences with respect to the molecular basis of cancer. |
Properties
| publication info | E. Helmreich, Oxford University Press, 2001, 368 pp., soft cover |
Table Of Contents
| Table of Contents | Part I: The machinery of signal transduction 1. Molecular basis of signal transduction 2. Activation of receptors by oligomerization 3. Components of signaling networks: linkers and regulators 4. Signal transduction pathways through small monomeric G proteins 5. Signal transduction pathways through heterotrimeric G proteins: transmission of hormonal and sensory signals 6. Signal transduction pathways through morphogenesis and haematopoiesis 7. Control of signaling by phosphorylation and dephosphorylation 8. Regulation by a hormone: the insulin response Part II: Cell Signaling and gene transcription 9. Machinery of Gene transcription 10. Regulation of gene transcription by growth factors and cytokines 11. Regulation of gene transcription by hormones Part III: Global cell regulatory programs 12. Regulation of the cell cycle 13. Regulation of cell death 14. Regulation of the immune response Part IV: Loss of regulatory control and its consequences 15. Transformation of normal cells to tumour cells 16. Loss of developmental controls in cancer 17. The causes of cancer Glossary |
